The DataContext

The Control.DataContext property describes where controls will look by default for values when binding. The data context will usually be set for top-level controls such as Window and child controls will inherit this data context.
When using the MVVM pattern, the data context will usually be an instance of a view model.
If you created your application with the Avalonia MVVM Application template then you will see something like this in your Program.cs file:
private static void AppMain(Application app, string[] args)
var window = new MainWindow
DataContext = new MainWindowViewModel(),
This means that when the MainWindow is created, a new instance of MainWindowViewModel will be created and assigned to the window's DataContext property. From here all bindings will by default bind to properties on this object:
<Button Content="{Binding ButtonCaption}"/>
Will bind the Button's Content to Window.DataContext.ButtonCaption.

Binding DataContext

Info: In the samples below we consider that we have a ViewModel that has a property named Content. Content itself is a class that has a property called Header.
When binding DataContext, the DataContext of the parent control is used as the source of the binding:
<!-- Will bind `DataContext` to `Window.DataContext.Content -->
<StackPanel DataContext="{Binding Content}"/>
Controls that display content based on a data template will automatically set the DataContext for the controls in the template. For example ContentControl:
<ContentControl Content="{Binding Content}">
<!-- Will bind `Text` to `Window.DataContext.Content.Header -->
<TextBlock Text="{Binding Header}"/>